Acetic Acid → HCID 23445202, compound

HRID 397918Notes

Reaction equation

HRID 397918 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([CH3:3])[CH3:2].[CH:11](OCC)(OCC)OCC.[N+:21]([CH2:24]C(OCC)=O)([O-])=O.[C:30]([OH:33])(=[O:32])[CH3:31]>[Fe]>[CH:1]([C:4]1[CH:5]=[C:6]([N:7]2[CH:11]=[C:31]([C:30]([OH:33])=[O:32])[N:21]=[CH:24]2)[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 176Acetic Acid2×HCID 31214Ethyl orthoformate2×HCID 69379Ethyl nitroacetateHCID 4586793-Isopropylaniline

Product 1

HCID 23445202HCID 23445202, compound

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

Following the general method described in example 234, 3-isopropylaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp.>122° C. dec. (H2O/dioxane), MS: m/e=231 (M+H+).

Sources & evidence

ORD record
ord-ee18639b7f3942ed9d4af627e99d2283
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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