反应详情

温度

70 °C

0.50 g (1.57 mmol) of benzyl 4-(2-cyclohexylethoxy)acetoacetate, 0.22 g (1.57 mmol) of 3-chlorobenzaldehyde and 0.24 g (1.57 mmol) of 2-cyanoethyl 3-aminocrotonate were stirred in 8 ml of 2-propanol under heating at 70° C. for 22 hours. After 2-propanol was evaporated under reduced pressure, the residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/2) to obtain the title compound.

1. customAfter 2-propanol was evaporated under reduced pressure
2. customthe residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/2)