Hydrochloric Acid → HCID 23001180, compound

Participants

Reaction Steps

0.065 g (0.10 mmol) of (2-cyanoethyl) 6-(2-aminoethoxy)methyl-4-(3-chlorophenyl)-5-(3,3-diphenylpropylcarbamoyl)-2-methoxymethyl-1,4-dihydropyridine-3-carboxylate was dissolved in 1 ml of methanol. 0.20 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 8 hours. The reaction mixture was neutralized with 1 N hydrochloric acid. After the extraction with ethyl acetate, the solvent was evaporated and the product was purified by TLC (Silanised Silica gel, methanol/water=6/4) to obtain the title compound.

Provenance & Evidence