Hydrochloric Acid → HCID 23001180, compound

HRID 397976Notes

Reaction equation

HRID 397976 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[NH:11][C:10]([CH2:12][O:13][CH3:14])=[C:9]([C:15]([O:17]CCC#N)=[O:16])[CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[C:7]=1[C:29](=[O:46])[NH:30][CH2:31][CH2:32][CH:33]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.[OH-].[Na+].Cl>CO>[NH2:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[NH:11][C:10]([CH2:12][O:13][CH3:14])=[C:9]([C:15]([OH:17])=[O:16])[CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[C:7]=1[C:29](=[O:46])[NH:30][CH2:31][CH2:32][CH:33]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69940360HCID 69940360, compound

Product 1

HCID 23001180HCID 23001180, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.065 g (0.10 mmol) of (2-cyanoethyl) 6-(2-aminoethoxy)methyl-4-(3-chlorophenyl)-5-(3,3-diphenylpropylcarbamoyl)-2-methoxymethyl-1,4-dihydropyridine-3-carboxylate was dissolved in 1 ml of methanol. 0.20 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 8 hours. The reaction mixture was neutralized with 1 N hydrochloric acid. After the extraction with ethyl acetate, the solvent was evaporated and the product was purified by TLC (Silanised Silica gel, methanol/water=6/4) to obtain the title compound.

Workup

  1. extractionAfter the extraction with ethyl acetate
  2. customthe solvent was evaporated
  3. customthe product was purified by TLC (Silanised Silica gel, methanol/water=6/4)

Sources & evidence

ORD record
ord-5c456f58675948d79ed371769fa977d6
Source dataset
uspto-grants-2003_08
Patent number
US06610717B2

Reaction notes

Loading…