Cyclopentylamine → HCID 70021884, compound

HRID 397980Notes

Reaction equation

HRID 397980 reaction equation
[C:1]([OH:4])(=[O:3])C.[NH2:5][C:6]1[N:14]=[C:13](Cl)[N:12]=[C:11]2[C:7]=1[N:8]=[CH:9][N:10]2[C@H:16]1[C@H:20]([OH:21])[C@H:19]([OH:22])[C@@H:18]([C:23]2[O:27][N:26]=[C:25]([CH3:28])[N:24]=2)[O:17]1.[CH:29]1([NH2:34])[CH2:33][CH2:32][CH2:31][CH2:30]1>CS(C)=O>[CH:1]([OH:4])=[O:3].[NH2:5][C:6]1[N:14]=[C:13]([NH:34][CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[N:12]=[C:11]2[C:7]=1[N:8]=[CH:9][N:10]2[C@H:16]1[C@H:20]([OH:21])[C@H:19]([OH:22])[C@@H:18]([C:23]2[O:27][N:26]=[C:25]([CH3:28])[N:24]=2)[O:17]1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 88113441HCID 88113441, compound

Product 1

HCID 70021884HCID 70021884, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Intermediate 17 (0.048 g), cyclopentylamine (0.06 ml) in DMSO (0.05 ml) were heated in a sealed vial (eg Reacti vial™) at 90° C. for 20 hrs. The crude material was purified by Autoprep HPLC, solvent was removed in vacuo and the residue freeze-dried to give the title compound as a pale yellow solid (0.006 g) LC/MS system A Rt=2.2 min, m/z=403(MH+)

Workup

  1. customThe crude material was purified by Autoprep HPLC, solvent
  2. customwas removed in vacuo
  3. customthe residue freeze-dried

Sources & evidence

ORD record
ord-0ed21ebd31894d88861a3d4514076264
Source dataset
uspto-grants-2003_08
Patent number
US06610665B1

Reaction notes

Loading…