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HRID397983

反应详情

EQUATION

反应方程式

HRID 397983 的结构方程式

REACTANTS

反应物

3
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

结构：CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](c2nc(C)no2)[C@@H](O)[C@H]1O
HCID56619484

未命名化合物

结构：N[C@H]1CC[C@H](N)CC1
HCID178511674

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CCC(CC)Nc1nc(N[C@H]2CC[C@H](N)CC2)nc2c1ncn2[C@@H]1O[C@H](c2nc(C)no2)[C@@H](O)[C@H]1O.O=CO
HCID178446277

未命名化合物

CONDITIONS

反应条件

温度
85 °C

PROCEDURE

实验过程

Intermediate 11 (0.069 g, 0.163 mmol) and trans-1,4-diaminocyclohexane (0.093 g, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 80-90° C. for 66 h in a sealed vial (eg Reacti vial™), a further portion of trans-1,4-diaminocyclohexane (0.093 g, 0.815 mmol) was added after the first 20 h. The product was purified by Autoprep. to give the title compound after freeze drying as a brown solid (0.063 g). LC/MS system B Rt=2.12 min, m/z=502 MH+.

WORKUP

后处理

  1. customThe product was purified by Autoprep