HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 397983Generated: October 25, 2026
Dimethyl Sulfoxide → HCID 178446277, compound
https://huagongshe.com/reaction/397983
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | (2r,3r,4s,5s)-2-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol | HCID 56619484 | — |
| Reactant | HCID 178511674 | HCID 178511674 | — |
| Product | HCID 178446277 | HCID 178446277 | — |
Reaction Steps
Intermediate 11 (0.069 g, 0.163 mmol) and trans-1,4-diaminocyclohexane (0.093 g, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 80-90° C. for 66 h in a sealed vial (eg Reacti vial™), a further portion of trans-1,4-diaminocyclohexane (0.093 g, 0.815 mmol) was added after the first 20 h. The product was purified by Autoprep. to give the title compound after freeze drying as a brown solid (0.063 g). LC/MS system B Rt=2.12 min, m/z=502 MH+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06610665B1 |
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| Source dataset | uspto-grants-2003_08 |
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| ORD ID | ord-fb19eab08b354a9ba28a1f0da9511c21 |
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| Source note | uspto-grants-2003_08 |
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