反应详情

温度

80 °C

Intermediate 9 (0.070 g, 0.161 mmol) and 2-piperidinoethylamine (0.115 ml, 0.807 mmol) were dissolved in DMSO (0.03 ml) and heated at 80° C. in a sealed vial (eg Reacti vial™), for 40 h, a further portion of 2-piperidinoethylamine (0.057 ml, 0.403 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a brown gum (0.035 g). LC/MS system B Rt=2.33 min, m/z=530 MH+.

1. customThe product was purified by Autoprep