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HRID397989

反应详情

EQUATION

反应方程式

HRID 397989 的结构方程式

REACTANTS

反应物

3
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

结构：CCc1noc([C@H]2O[C@@H](n3cnc4c(NC(CC)CC)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1
HCID56625647

未命名化合物

结构：N[C@H]1CC[C@H](N)CC1
HCID178511674

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CCc1noc([C@H]2O[C@@H](n3cnc4c(NC(CC)CC)nc(N[C@H]5CC[C@H](N)CC5)nc43)[C@H](O)[C@@H]2O)n1.O=CO
HCID178438089

未命名化合物

CONDITIONS

反应条件

温度
85 °C

PROCEDURE

实验过程

Intermediate 9 (0.070 g, 0.161 mmol) and trans-1,4-diaminocyclohexane (0.092 g, 0.807 mmol) were dissolved in DMSO (0.03 ml) and heated at 80-90° C. in a sealed vial (eg Reacti vial™), for 66 h, a further portion of trans-1,4-diaminocyclohexane (0.092 mg, 0.807 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a brown solid (0.082 g). LC/MS system B Rt=2.21 min, m/z=516 MH+.

WORKUP

后处理

  1. customThe product was purified by Autoprep