HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 397989Generated: October 27, 2026
Dimethyl Sulfoxide → HCID 178438089, compound
https://huagongshe.com/reaction/397989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | (2r,3r,4s,5s)-2-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-5-(3-ethyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol | HCID 56625647 | — |
| Reactant | HCID 178511674 | HCID 178511674 | — |
| Product | HCID 178438089 | HCID 178438089 | — |
Reaction Steps
Intermediate 9 (0.070 g, 0.161 mmol) and trans-1,4-diaminocyclohexane (0.092 g, 0.807 mmol) were dissolved in DMSO (0.03 ml) and heated at 80-90° C. in a sealed vial (eg Reacti vial™), for 66 h, a further portion of trans-1,4-diaminocyclohexane (0.092 mg, 0.807 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a brown solid (0.082 g). LC/MS system B Rt=2.21 min, m/z=516 MH+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06610665B1 |
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| Source dataset | uspto-grants-2003_08 |
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| ORD ID | ord-37cb9e42a06d44d5bd25cb9517bb0f91 |
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| Source note | uspto-grants-2003_08 |
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