HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 23001300, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | HCID 23001283 | HCID 23001283 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 23001300 | HCID 23001300 | — |
Reaction Steps
A solution of the product from Step B in DMF reacts with N-Boc glycine (1.1 eq), EDC (1.1 eq) and HOBT (1 eq). When the reaction is complete, ethyl acetate and water are added, and the organic phase is washed 5 times with water, once with saturated NaCl, and dried over magnesium sulfate. Filtration and evaporation provides the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610722B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-98cf964d727d4ad98ec720102f10f19c |
| Source note | uspto-grants-2003_08 |