HRID397996

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID78288

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-

C7H13NO4

结构：CC(C)(C)[Si](Oc1ccc(Br)c(CN)c1)(c1ccccc1)c1ccccc1

HCID23001283

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCC(=O)NCc1cc(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)ccc1Br

HCID23001300

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A solution of the product from Step B in DMF reacts with N-Boc glycine (1.1 eq), EDC (1.1 eq) and HOBT (1 eq). When the reaction is complete, ethyl acetate and water are added, and the organic phase is washed 5 times with water, once with saturated NaCl, and dried over magnesium sulfate. Filtration and evaporation provides the title compound.

WORKUP

后处理

washthe organic phase is washed 5 times with water
dry with materialonce with saturated NaCl, and dried over magnesium sulfate
filtrationFiltration and evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98cf964d727d4ad98ec720102f10f19c
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06610722B2
来源说明: uspto-grants-2003_08

反应 SMILES

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][Si:9]([C:22]([CH3:25])([CH3:24])[CH3:23])([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][C:3]=1[CH2:26][NH2:27].[C:28]([NH:35][CH2:36][C:37](O)=[O:38])([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][Si:9]([C:22]([CH3:23])([CH3:24])[CH3:25])([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:4][C:3]=1[CH2:26][NH:27][C:37](=[O:38])[CH2:36][NH:35][C:28]([O:30][C:31]([CH3:33])([CH3:32])[CH3:34])=[O:29]