Trifluoroacetic acid → HCID 23001299, compound

HRID 398002Notes

Reaction equation

HRID 398002 reaction equation
FC(F)(F)C(O)=O.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][Si:16]([C:29]([CH3:32])([CH3:31])[CH3:30])([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][C:10]=1[NH:33][CH2:34][CH2:35][NH:36]C(OC(C)(C)C)=O>C(Cl)Cl>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][Si:16]([C:29]([CH3:31])([CH3:32])[CH3:30])([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:11][C:10]=1[NH:33][CH2:34][CH2:35][NH2:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23001280HCID 23001280, compound

Product 1

HCID 23001299HCID 23001299, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid is added to a solution of product from Step A in methylene chloride. After one hour at room temperature, the solution is evaporated, and the residue is partitioned between ethyl acetate and saturated aqueous sodium bicarbonate solution. The organic phase is washed with saturated NaCl, dried over magnesium sulfate, filtered and evaporated to provide the title compound.

Workup

  1. customthe solution is evaporated
  2. customthe residue is partitioned between ethyl acetate and saturated aqueous sodium bicarbonate solution
  3. washThe organic phase is washed with saturated NaCl
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-ff506f164e4047538872dd9d58615170
Source dataset
uspto-grants-2003_08
Patent number
US06610722B2

Reaction notes

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