2-Methyl-2-butene → HCID 23001304, compound

HRID 398010Notes

Reaction equation

HRID 398010 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:13]3[C:14]([CH:17]=[O:18])=[CH:15][N:16]=[C:12]3[CH2:11][CH2:10]2)=[CH:5][C:4]=1[F:19])#[N:2].CC(=CC)C.Cl([O-])=[O:26].[Na+].O.P([O-])(O)(O)=O.[Na+]>C(O)(C)(C)C.O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:13]3[C:14]([C:17]([OH:26])=[O:18])=[CH:15][N:16]=[C:12]3[CH2:11][CH2:10]2)=[CH:5][C:4]=1[F:19])#[N:2]

Participants

7

Reactant 4

HCID 105532-Methyl-2-buteneHCID 516949Sodium Phosphate, Monobasic, MonohydrateHCID 23001307HCID 23001307, compoundHCID 23668197Sodium Chlorite

Product 1

HCID 23001304HCID 23001304, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6386tert-ButanolSolvent

Procedure

To a solution of aldehyde from Step J (990 mg, 3.88 mmol) in tert-butanol (20 mL)/2-methyl-2-butene (2 mL) was added a solution of sodium chlorite (421 mg, 4.65 mmol) and sodium dihydrogenphosphate monohydrate (642 mg, 4.65 mmol) in H2O (4 mL). The reaction mixture was stirred for 16 hours and the precipitate filtered to yield the title product as a white solid.

Workup

  1. filtrationthe precipitate filtered

Sources & evidence

ORD record
ord-ef840162b4f74ee3b240c7c5cf926eab
Source dataset
uspto-grants-2003_08
Patent number
US06610722B2

Reaction notes

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