HCID 23001302, compound → HCID 70025062, compound

HRID 398013Notes

Reaction equation

HRID 398013 reaction equation
[N:1]([CH2:4][CH2:5][C:6]#[C:7][C:8]1[CH:9]=[C:10]([CH:29]=[CH:30][CH:31]=1)[O:11][Si:12]([C:25]([CH3:28])([CH3:27])[CH3:26])([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[N+]=[N-]>[Pd].CO>[Si:12]([O:11][C:10]1[CH:9]=[C:8]([CH2:7][CH2:6][CH2:5][CH2:4][NH2:1])[CH:31]=[CH:30][CH:29]=1)([C:25]([CH3:26])([CH3:27])[CH3:28])([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 23001302HCID 23001302, compound

Product 1

HCID 70025062HCID 70025062, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of azide from Step C (57.0 mg, 0.134 mmol) and 10% palladium on carbon (57.0 mg) in methanol (5 mL) was placed under a hydrogen atmosphere (1 atm) for 16 hours. The reaction mixture was filtered through a Celite pad and concentrated in vacuo to provide the title compound.

Workup

  1. customfor 16 hours
  2. filtrationThe reaction mixture was filtered through a Celite pad
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3303d2cf3cf74e7abdcf44f85f387153
Source dataset
uspto-grants-2003_08
Patent number
US06610722B2

Reaction notes

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