反应详情

A mixture of 5-(4-fluorophenyl)-4-(4-pyridyl)-2-(1H)-pyrimidinone (2.41 mmol) and phosphorus oxychloride (3 ml) was heated at reflux for 45 min. It was evaporated to dryness at a bath temperature of >500° C. The flask was cooled in an ice-bath and ice-water was added. If the pH value was found still acidic, then the mixture was neutralized with aqueous 5% ammonium hydroxide. It was extracted with dichloromethane, followed by washing of the organic solution with aqueous sodium chloride, drying and evaporation to yield the title compound as a yellowish foam which was used without further purification.

1. temperaturewas heated
2. temperatureat reflux for 45 min
3. customIt was evaporated to dryness at a bath temperature of >500° C
4. temperatureThe flask was cooled in an ice-bath
5. additionice-water was added
6. extractionIt was extracted with dichloromethane
7. washby washing of the organic solution with aqueous sodium chloride
8. customdrying
9. customevaporation