1-(2-Fluorophenyl)-1,3-propanediamine → 2-Chloro-5-(4-fluorophenyl)-4-(4-pyridyl)-pyrimidine

HRID 398028Notes

Reaction equation

HRID 398028 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C(F)(F)F)[CH:15]=2)=[CH:4][N:3]=1.[F:24]C1C=CC=CC=1C(N)CCN>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[C:5]([C:14]2[CH:19]=[CH:18][C:17]([F:24])=[CH:16][CH:15]=2)=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 223465761-(2-Fluorophenyl)-1,3-propanediamineHCID 538430352-Chloro-4-(4-pyridyl)-5-(3-trifluoromethylphenyl)-pyrimidine

Product 1

HCID 230003652-Chloro-5-(4-fluorophenyl)-4-(4-pyridyl)-pyrimidine

Procedure

2-Chloro-4-(4-pyridyl)-5-(3-trifluoromethylphenyl)-pyrimidine and 1-(2-fluorophenyl)-1,3-propanediamine were reacted according to the General Procedure, Step C (100° C. for 30 min) to give the title compound. MS (m/z): 468.4 (M+H)+; C25H21F4N5 requir. 467.5 (free base).

Workup

  1. customaccording to the General Procedure, Step C (100° C. for 30 min)

Sources & evidence

ORD record
ord-8a3a36f06a9441a8bacf16297ef0f063
Source dataset
uspto-grants-2003_08
Patent number
US06610698B2

Reaction notes

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