Acetic Anhydride → HCID 54287785, compound

HRID 398029Notes

Reaction equation

HRID 398029 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[N:12]1[CH:17]=[CH:16][C:15]([CH:18]=O)=[CH:14][CH:13]=1.C(OC(=O)C)(=O)C>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[CH:18][C:15]2[CH:16]=[CH:17][N:12]=[CH:13][CH:14]=2)[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 98372-(4-Fluorophenyl)acetic acidHCID 133894-Pyridinecarboxaldehyde

Product 1

HCID 54287785HCID 54287785, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 4-fluorophenylacetic acid (9 g, 58.4 mmol), 4-pyridinecarboxaldehyde (5.6 ml, 58.6 mmol), pyridine (6 ml) and acetic anhydride (6 ml) was heated at 150° C. for 1 h followed by evaporation and co-distillation with water. The resulting material crystallized on addition of ethanol. The solids were filtered and washed with ethanol and ethyl acetate to provide the title compound.

Workup

  1. customfollowed by evaporation and co-distillation with water
  2. customThe resulting material crystallized on addition of ethanol
  3. filtrationThe solids were filtered
  4. washwashed with ethanol and ethyl acetate

Sources & evidence

ORD record
ord-28140469e1f74413b989077d0376e9a1
Source dataset
uspto-grants-2003_08
Patent number
US06610698B2

Reaction notes

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