反应详情

To 2.0 mL of ethyl acetate solution containing 25 mg of N-methyl-2-oxo-1-(2-(4-(((5-(2-thienyl)isooxazol-3-yl)methyl)amino)piperidin-1-yl)ethyl)-1,2-dihydroquinoline-4-carboxamide, 0.5 mL of 4.0 mol/L hydrogen chloride/ethyl acetate solution was added under ice-cooling. The mixture was stirred at the same temperature for 10 min, and the solvent was removed under reduced pressure. To the residue thus obtained, ethyl acetate was added, the resulting solid was filtered to give 23 mg of N-methyl-2-oxo-1-(2-(4-(((5-(2-thienyl)isooxazol-3-yl)methyl)amino)piperidin-1-yl)ethyl)-1,2-dihydroquinoline-4-carboxamide hydrochloride as a light brown solid.

1. additionwas added under ice-
2. temperaturecooling
3. customthe solvent was removed under reduced pressure
4. customTo the residue thus obtained
5. filtrationthe resulting solid was filtered