HCID 23000277, compound → 4-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

HRID 398343Notes

Reaction equation

HRID 398343 reaction equation
[C:1]([C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH2:7][CH2:6]2)#[N:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2)#[N:2]

Participants

4

Reactant 1

HCID 23000277HCID 23000277, compound

Product 1

HCID 230002374-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 5-cyano-4-methyl-7-azaindoline (52 mg, 0.33 mmol) and manganese dioxide (130 mg, 1.5 mmol) in chloroform (10 mL) was stirred for 16 h and then was filtered through celite, washing through with chloroform followed by methanol. The filtrate was evaporated in vacuo to give the title compound as a tan solid:

Workup

  1. filtrationwas filtered through celite
  2. washwashing through with chloroform
  3. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-dd8fbfc54c8a4cd68855d8c458a08a9c
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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