Hydrochloric Acid → HCID 23000268, compound

HRID 398344Notes

Reaction equation

HRID 398344 reaction equation
[C:1]([C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2)#[N:2].[ClH:13]>[Pd].CO>[ClH:13].[ClH:13].[NH2:2][CH2:1][C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 230002374-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Product 1

HCID 23000268HCID 23000268, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 5-cyano-4-methyl-7-azaindole (48 mg, 0.31 mmol) and 10% palladium on carbon (25 mg) in methanol (10 mL) and concentrated HCl (0.5 mL) was shaken on a Parr apparatus under hydrogen (50 psi) for 6 h. The mixture was filtered through celite and evaporated in vacuo. The residue was dissolved in a minimum volume of methanol, ether was added and the solids collected by filtration to give the title compound as a pale yellow solid:

Workup

  1. filtrationThe mixture was filtered through celite
  2. customevaporated in vacuo
  3. dissolutionThe residue was dissolved in a minimum volume of methanol, ether
  4. additionwas added
  5. filtrationthe solids collected by filtration

Sources & evidence

ORD record
ord-7028770566d54bfeaa225807ee369b91
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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