Methanol → HCID 67539287, compound

HRID 39836Notes

Reaction equation

HRID 39836 reaction equation
CO.[CH:3]1([C:6]2[CH:15]=[C:14]3[C:9]([C:10]([CH3:44])=[CH:11][C:12](=[O:43])[N:13]3[CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH:21]([N:24]([CH2:32][C:33]4[CH:42]=[CH:41][C:36]5[O:37][CH2:38][CH2:39][O:40][C:35]=5[CH:34]=4)C(=O)OC(C)(C)C)[CH2:20][CH2:19]3)=[CH:8][CH:7]=2)[CH2:5][CH2:4]1.[ClH:45].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:45].[CH:3]1([C:6]2[CH:15]=[C:14]3[C:9]([C:10]([CH3:44])=[CH:11][C:12](=[O:43])[N:13]3[CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH:21]([NH:24][CH2:32][C:33]4[CH:42]=[CH:41][C:36]5[O:37][CH2:38][CH2:39][O:40][C:35]=5[CH:34]=4)[CH2:20][CH2:19]3)=[CH:8][CH:7]=2)[CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 887MethanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 59397906HCID 59397906, compound

Product 1

HCID 67539287HCID 67539287, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1 mL of methanol solution containing 95 mg of tert-butyl (1-(2-(7-cyclopropyl-4-methyl-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature, and stirred for 1.5 hours. Ethyl acetate was added, and the resulting solid was filtered to give 45 mg of 7-cyclopropyl-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-4-methylquinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. additionwas added at room temperature
  2. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-6502ecfbf258413c87316c0be9587563
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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