Triethylamine → HCID 23000170, compound

HRID 398366Notes

Reaction equation

HRID 398366 reaction equation
[CH:1]1([CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 230002215687-83-2

Product 1

HCID 23000170HCID 23000170, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred 0° C. solution of 683 mg (6.0 mmol) of 4-cyclopropylbutanol and 1.25 mL (9.0 mmol) of triethylamine in 10 mL of CH2Cl2 was added 697 μL (9.0 mmol) of methanesulfonyl chloride dropwise under Ar. The cold bath was allowed to expire over a 2 h period at which time the reaction mixture was diluted with CH2Cl2, washed with cold 1M HCl, water, sat. NaHCO3, brine, dried over MgSO4 and the solvents removed to give the title compound as a yellow oil:

Workup

  1. washwashed with cold 1M HCl, water, sat. NaHCO3, brine
  2. dry with materialdried over MgSO4
  3. customthe solvents removed

Sources & evidence

ORD record
ord-ffeb22255aad496b8c70f40a043f0a49
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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