HCID 23000187, compound → HCID 54725781, compound

HRID 398374Notes

Reaction equation

HRID 398374 reaction equation
C([O:8][C:9]1[C:10](=[O:35])[N:11]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C:12]([CH3:26])=[CH:13][C:14]=1[C:15]([N:17]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[C:10](=[O:35])[N:11]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:32])[CH3:33])=[O:29])[C:12]([CH3:26])=[CH:13][C:14]=1[C:15]([N:17]([CH2:22][CH:23]([CH3:24])[CH3:25])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]

Participants

4

Reactant 1

HCID 23000187HCID 23000187, compound

Product 1

HCID 54725781HCID 54725781, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 3-benzyloxy-4-diisobutylaminocarbonyl-6-methyl-1-tert-butyloxycarbonylmethyl-2-pyridinone from step 4 above (0.80 g) and 10% Pd on carbon (180 mg) in ethanol (40 mL) was shaken on a Parr apparatus under an atmosphere of hydrogen (50 psi) for 18 h. The catalyst was removed by filtration and the filtrate solvents were removed in vacuo to give the title compound (0.608 g;

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate solvents were removed in vacuo

Sources & evidence

ORD record
ord-ae3967df5b1c4f24b3022373f7fa0d07
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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