Trifluoroacetic acid → HCID 54725780, compound

HRID 398375Notes

Reaction equation

HRID 398375 reaction equation
[OH:1][C:2]1[C:3](=[O:28])[N:4]([CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[C:5]([CH3:19])=[CH:6][C:7]=1[C:8]([N:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:9].C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:1][C:2]1[C:3](=[O:28])[N:4]([CH2:20][C:21]([OH:23])=[O:22])[C:5]([CH3:19])=[CH:6][C:7]=1[C:8]([N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:15][CH:16]([CH3:17])[CH3:18])=[O:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54725781HCID 54725781, compound

Product 1

HCID 54725780HCID 54725780, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution 3-hydroxy-4-diisobutylaminocarbonyl-6-methyl-1-tert-butyloxycarbonylmethyl-2-pyridinone from step 5 above (0.61 g) in CH2Cl2 (4 mL) was added TFA (2 mL) and the solution was stirred at ambient temperature for 32 h. The solvents were removed in vacuo to give the title compound (0.6 g; HPLC RT=13.56 min, method B).

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-6e76be06b19142d3a60df7cfb5d0c8da
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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