Acetic Anhydride → HCID 18969122, compound

HRID 398829Notes

Reaction equation

HRID 398829 reaction equation
[CH:1]1([C:7]([C:9]2[C:10]([NH:15][CH2:16][CH3:17])=[N:11][CH:12]=[CH:13][CH:14]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(O[C:22](=[O:24])[CH3:23])(=O)C>>[CH:1]1([C:7]([C:9]2[C:10]([N:15]([CH2:16][CH3:17])[C:22](=[O:24])[CH3:23])=[N:11][CH:12]=[CH:13][CH:14]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 23284484HCID 23284484, compound

Product 1

HCID 18969122HCID 18969122, compound

Procedure

An acetic anhydride solution (20 ml) of 1.5 g of 3-cyclohexylcarbonyl-2-ethylaminopyridine was heated under reflux for 4 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (toluene-ethyl acetate) to give 1.1 g of N-(3-cyclohexylcarbonyl-2-pyridyl) -N-ethylacetamide.

Workup

  1. temperatureunder reflux for 4 hours
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography (toluene-ethyl acetate)

Sources & evidence

ORD record
ord-750b11af916040ef97eae0cf101cac76
Source dataset
uspto-grants-1998_10
Patent number
US05817670

Reaction notes

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