反应详情

To 0.32 g of 1-(1,3-dioxolan-2-ylmethyl)-7-dimethylamino-4-methylquinolin-2(1H)-one, 3 mL of 90% aqueous trifluoroacetic acid solution was added, and stirred at room temperature for four days, the solvent was removed under reduced pressure, ethyl acetate and aqueous saturated sodium hydrogen carbonate solution were added, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and extracts were combined, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give 0.16 g of (7-dimethylamino-4-methyl-2-oxoquinolin-1(2H)-yl)acetaldehyde as a yellow foam.

1. customthe solvent was removed under reduced pressure, ethyl acetate and aqueous saturated sodium hydrogen carbonate solution
2. additionwere added
3. customthe organic layer was separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was removed under reduced pressure