Thionyl Chloride → 2,6-Dichlorpyridine-3-carbonyl chloride

HRID 398842Notes

Reaction equation

HRID 398842 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:14])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 8540472,6-Dichloronicotinic acid

Product 1

HCID 122639842,6-Dichlorpyridine-3-carbonyl chloride

Procedure

(1)-2 A mixture of 2,6-dichloronicotinic acid (50.6 g) with thionyl chloride (100 ml) was refluxed for 2 hours. The excess thionyl chloride was distilled off under reduced pressure, and crude product was distilled under reduced pressure to give 2,6-dichloronicotinoyl chloride (44.9 g).

Workup

  1. temperaturewas refluxed for 2 hours
  2. distillationThe excess thionyl chloride was distilled off under reduced pressure, and crude product
  3. distillationwas distilled under reduced pressure

Sources & evidence

ORD record
ord-f1c0d6bdb2d04c7984643587a80f488d
Source dataset
uspto-grants-1998_10
Patent number
US05817669

Reaction notes

Loading…