Isobutyryl chloride → HCID 19601540, compound

HRID 398864Notes

Reaction equation

HRID 398864 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[CH3:18][CH:19]([CH3:23])[C:20](Cl)=[O:21]>>[CH3:18][CH:19]([CH3:23])[C:20]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)=[O:21]

Participants

3

Reactant 2

HCID 62325Isobutyryl chlorideHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 19601540HCID 19601540, compoundYield 756.6%

Procedure

Beginning with 0.35 gm (0.154 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.20 mL (0.193 mMol) 2-methylpropanoyl chloride, 0.35 gm (75%) of the title compound were prepared essentially by the procedure described in Example 8.

Sources & evidence

ORD record
ord-3ab4171fdc09411699593ce3ccfae908
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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