Sodium Hydroxide → HCID 18969229, compound

HRID 398997Notes

Reaction equation

HRID 398997 reaction equation
[C:1]1([C:7]2[N:16]=[C:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([O:32]C)=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[N:16]=[C:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([OH:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19595375HCID 19595375, compound

Product 1

HCID 18969229HCID 18969229, compoundYield 64.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

240 mg of the product of Example 22 were introduced into 2 ml of ethanol and 0155 ml of 2N sodium hydroxide were added. The solution was stirred for 2 days at ambient temperature and then was refluxed for 2 hours. The solution was evaporated to dryness and the residue was taken up in water and neutralized with concentrated hydrochloric acid. The precipiate was filtered, dried and crystallized from a water-isopropyl alcohol mixture 10-90 to obtain 150 mg of the expected product melting at 210° C.

Workup

  1. additionwere added
  2. temperaturewas refluxed for 2 hours
  3. customThe solution was evaporated to dryness
  4. filtrationThe precipiate was filtered
  5. customdried
  6. customcrystallized from a water-isopropyl alcohol mixture 10-90

Sources & evidence

ORD record
ord-88591dafc91e4aeaa3bb5f345ce733db
Source dataset
uspto-grants-1998_10
Patent number
US05817674

Reaction notes

Loading…