Sodium Hydroxide → HCID 18969229, compound

Participants

Reaction Steps

240 mg of the product of Example 22 were introduced into 2 ml of ethanol and 0155 ml of 2N sodium hydroxide were added. The solution was stirred for 2 days at ambient temperature and then was refluxed for 2 hours. The solution was evaporated to dryness and the residue was taken up in water and neutralized with concentrated hydrochloric acid. The precipiate was filtered, dried and crystallized from a water-isopropyl alcohol mixture 10-90 to obtain 150 mg of the expected product melting at 210° C.

Provenance & Evidence