O-Methylhydroxylamine hydrochloride → HCID 136041256, compound

HRID 399003Notes

Reaction equation

HRID 399003 reaction equation
Cl.[CH3:2][O:3][NH2:4].[NH:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10](=O)[C:11]([O:13][CH3:14])=[O:12]>CO>[CH3:2][O:3][N:4]=[C:10]([C:6]1[NH:5][CH:9]=[CH:8][CH:7]=1)[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 18370696HCID 18370696, compound

Product 1

HCID 136041256HCID 136041256, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

97.5 g (1.2 eq) of methoxyamine hydrochloride are added to a solution of 148.8 g (0.97 mol) of methyl pyrrol-2-ylglyoxylate (prepared by a method similar to that described by B. Lindstrom et al., Acta Chem. Scand. 27 (1973), 7) in 1 l of methanol, and the solution is refluxed for 2.5 hours. After evaporation in a rotary evaporator, the residue is taken up in ethyl acetate and the solution is washed with water, dried and evaporated down. 81 g (46%) of the pyrrole remained in the form of an oil.

Workup

  1. customprepared by a method similar to
  2. customAfter evaporation
  3. customin a rotary evaporator
  4. washthe solution is washed with water
  5. customdried
  6. customevaporated down

Sources & evidence

ORD record
ord-46b1336ed14b4c2891d8563d169dc154
Source dataset
uspto-grants-1998_10
Patent number
US05817682

Reaction notes

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