1,2-dihydroisoquinoline → HCID 10592220, compound

HRID 399014Notes

Reaction equation

HRID 399014 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2.[CH2:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][NH:17]1>CS(C)=O>[CH2:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18][N:17]1[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2

Participants

4

Reactant 2

HCID 4225111,2-dihydroisoquinolineHCID 10704607HCID 10704607, compound

Product 1

HCID 10592220HCID 10592220, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-(2-Chloroethoxy)-7-fluoro-1,3-dihydro-indol-2-one was reacted with dihydroisoquinoline in anhydrous dimethyl sulfoxide in the same manner described for intermediate 16 to afford the title compound in 45% yield. The fumarate salt was made in ethanol: mp 230°-235° C.

Sources & evidence

ORD record
ord-9b8aebd8fa6b4dc89d05c177aef8c17c
Source dataset
uspto-grants-1998_10
Patent number
US05817690

Reaction notes

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