反应详情

6-Hydroxyindole (2.9 g), methyl chloroacetate (2.7 g), potassium carbonate (5.5 g) and potassium iodide (0.2 g) are added to acetone (100 ml), and the mixture is refluxed for 8 hours. The reaction mixture is cooled to room temperature, and the insoluble materials are removed by filtration. The filtrate is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform) to give 6-methoxycarbonylmethoxyindole (2.83 g).

1. temperaturethe mixture is refluxed for 8 hours
2. customthe insoluble materials are removed by filtration
3. customThe filtrate is evaporated under reduced pressure
4. customThe residue is purified by silica gel column chromatography (eluent; chloroform)