Sodium Hydroxide → (3-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-1H-indol-7-yloxy)-acetic acid

HRID 399020Notes

Reaction equation

HRID 399020 reaction equation
C[O:2][C:3]([CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:15]=1[NH:14][CH:13]=[C:12]2[CH2:16][CH:17]([NH:19][CH2:20][C@@H:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=1)[OH:22])[CH3:18])=[O:4].[OH-].[Na+]>CO>[C:3]([CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:15]=1[NH:14][CH:13]=[C:12]2[CH2:16][CH:17]([NH:19][CH2:20][C@@H:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=1)[OH:22])[CH3:18])([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11373418HCID 11373418, compound

Product 1

HCID 6916441(3-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-1H-indol-7-yloxy)-acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound obtained in Example 14 and sodium hydroxide are added to an aqueous methanol solution (methanol/water=2:1), and the mixture is treated in the same manner as in Example 13 to give the desired compound.

Workup

  1. additionthe mixture is treated in the same manner as in Example 13

Sources & evidence

ORD record
ord-3731a555d3734aa1856e8901a5779538
Source dataset
uspto-grants-1998_10
Patent number
US05817689

Reaction notes

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