Water → 2-(p-Chlorophenyl)-4-[(3,4-dichlorophenyl)sulfonyl]-5-(trifluoromethyl)pyrrole-3-carbonitrile

HRID 399036Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:24]([F:27])([F:26])[F:25])=[C:11]([S:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)[C:12]=2[C:13]#[N:14])=[CH:4][CH:3]=1.S([O-])(O[O-])(=O)=[O:29].[K+].[K+].[OH2:36]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:24]([F:26])([F:27])[F:25])=[C:11]([S:15]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)(=[O:29])=[O:36])[C:12]=2[C:13]#[N:14])=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 25 °C

Procedure

A solution of 2-(p-chlorophenyl)-4-[(3,4-dichlorophenyl)thio]-5-(trifluoromethyl)pyrrole-3-carbonitrile (1.0 g, 2.2 mmol) in methanol is treated with a solution of potassium peroxymonosulfate (2.95 g) in water (7.4 mL), stirred at 25° C. for 24 hours, diluted with additional methanol, treated with a solution of potassium peroxymonosulfate (2.7 g) in water (7.6 mL), stirred at 25° C. for 24 hours, and filtered to obtain a solid which is washed with water and dried to give the title product a white solid (mp >225° C.).

Workup

stirringstirred at 25° C. for 24 hours
filtrationfiltered
customto obtain a solid which
washis washed with water
customdried

Sources & evidence

ORD record: ord-807fd2ef2d954439b65599f2a034137a
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817691

Reaction notes

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