反应详情

A mixture of (±) cis 1-amino-2-hydroxymethylcyclopentane (0.59 g, 5.1 mmol) and phthalic anhydride (0.76 g, 5.1 mmol) in xylene (40 ml) was heated under argon at reflux using a condenser fitted with a Dean and Stark trap. After 1.5 h the reaction was concentrated in vacuo and the residue was purified by column chromatography on silica gel eluting with diethyl ether to give the title compound as a pale yellow oil (1.0 g).

1. temperaturewas heated under argon
2. temperatureat reflux
3. customfitted with a Dean and Stark trap
4. concentrationAfter 1.5 h the reaction was concentrated in vacuo
5. customthe residue was purified by column chromatography on silica gel eluting with diethyl ether