Triethylamine → HCID 67573252, compound

HRID 399047Notes

Reaction equation

HRID 399047 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)([CH3:17])[CH3:16])=[CH:11][CH:10]=1.C(N(CC)CC)C.Cl[C:33]([O:35][CH2:36][CH3:37])=[O:34]>C(OCC)C>[CH2:36]([O:35][C:33]([NH:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)([CH3:17])[CH3:16])=[CH:11][CH:10]=1)=[O:34])[CH3:37]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 70070680HCID 70070680, compound

Product 1

HCID 67573252HCID 67573252, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of (±) cis -1-amino-2-[4-(1-(4-fluorophenyl)-1-methylethyl)phenoxymethyl] cyclopentane (0.58 g, 1.77 mmol) in dry diethyl ether (30 ml) containing triethylamine (0.49 ml, 3.54 mmol) was added a solution of ethyl chloroformate (0.29 g, 2.66 mmol) in diethyl ether (5 ml). The reaction was worked up as described in Preparation 8, and the resulting yellow oil (0.62 g) was used directly in the next stage.

Workup

  1. customas described in Preparation 8

Sources & evidence

ORD record
ord-c301ca9099dd4493a104859bf9b1a10d
Source dataset
uspto-grants-1998_10
Patent number
US05817698

Reaction notes

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