1,1'-Carbonyldiimidazole → HCID 10567719, compound

HRID 399050Notes

Reaction equation

HRID 399050 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=O)=[N:2]1.[C:13]([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)(N1C=CN=C1)=O>>[CH2:21]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:13][N:20]1[CH2:24][CH2:23][NH:22][C:10]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][N:2]=1)=[O:12]

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 78250Indazole-3-carboxylic acid

Product 1

HCID 10567719HCID 10567719, compoundYield 185.2%

Procedure

Same procedure followed as described in Example 5. The following amounts were used: 1H-indazole-3-carboxylic acid (1.49 g, 9.2 mmol), 1,1'-carbonyldiimidazole (1.49 g, 9.2 mmol) and the intermediate from Preparation 5 (1.62 g, 9.2 mmol). The ethyl acetate extracts were evaporated to a solid. Addition of cyclohexane and filtration provided 2.73 g of solid. Mass spectrum, m+ =321.

Workup

  1. customThe ethyl acetate extracts were evaporated to a solid
  2. additionAddition of cyclohexane and filtration

Sources & evidence

ORD record
ord-f3463eabf5a645538349ae96395ae908
Source dataset
uspto-grants-1998_10
Patent number
US05817676

Reaction notes

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