反应详情

To a solution of Example 1 (810 mg) in THF (20 mL) at 0° C. was added Tebbe's reagent (0.5M, 5 mL) dropwise. The mixture was stirred at r.t. for 30 min., quenched with NaOH 0.5N at 0° C. and diluted with Et2O. The organic phase was washed with H2O, brine, dried (MgSO4) and the solvents evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (95:5)) provided the title compound as a yellow oil.

1. customquenched with NaOH 0.5N at 0° C.
2. additiondiluted with Et2O
3. washThe organic phase was washed with H2O, brine
4. dry with materialdried (MgSO4)
5. customthe solvents evaporated