Trifluoroacetic acid → HCID 70274442, compound

HRID 399112Notes

Reaction equation

HRID 399112 reaction equation
C(OC([N:8]1[CH2:13][C@H:12]([C:14](=[O:32])[NH:15][CH2:16][CH2:17][C:18]2[N:22]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:21]=[N:20][CH:19]=2)[CH2:11][C@H:10]([C:33]([O:35][CH3:36])=[O:34])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:36][O:35][C:33]([C@H:10]1[CH2:11][C@@H:12]([C:14](=[O:32])[NH:15][CH2:16][CH2:17][C:18]2[N:22]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:21]=[N:20][CH:19]=2)[CH2:13][NH:8][CH2:9]1)=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70274380HCID 70274380, compound

Product 1

HCID 70274442HCID 70274442, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(t-Butoxycarbonyl)-cis-3-methoxycarbonyl-5-[N-(1-(4- cyanobenzyl)-1H-imidazol-5-ylethyl)carbamoyl]piperidine (1.14 g, 2.30 mmol) was dissolved in CH2Cl2 (12 mL). Trifluoroacetic acid (6 mL) was added and the solution was stirred at ambient temperature for 3 h. The solution was concentrated to dryness to give the title compound.

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-26e5a7d50baf4a978cfbc221e7142f29
Source dataset
uspto-grants-1998_10
Patent number
US05817678

Reaction notes

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