Trifluoroacetic acid → HCID 70273938, compound

HRID 399121Notes

Reaction equation

HRID 399121 reaction equation
C(OC([N:8]1[CH2:13][CH:12]([NH:14][C:15](=[O:31])[CH2:16][C:17]2[N:21]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=3)[CH:20]=[N:19][CH:18]=2)[CH2:11][CH:10]([C:32]([O:34][CH3:35])=[O:33])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:35][O:34][C:32]([C@H:10]1[CH2:11][C@@H:12]([NH:14][C:15](=[O:31])[CH2:16][C:17]2[N:21]([CH2:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]#[N:30])=[CH:27][CH:28]=3)[CH:20]=[N:19][CH:18]=2)[CH2:13][NH:8][CH2:9]1)=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23291157HCID 23291157, compound

Product 1

HCID 70273938HCID 70273938, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(t-Butoxycarbonyl)-3-methoxycarbonyl-5-[N-(1-(4-cyanobenzyl)-1H-imidazol-5-yl)acetylamino]piperidine (44.6 mg, 0.093 mmol) was dissolved in CH2Cl2 (6 mL). Trifluoroacetic acid (3 mL) was added and the solution was stirred at ambient temperature for 4 h. The solution was concentrated under reduced pressure to give the title compound without further purification.

Workup

  1. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3a4596e0709f446b9b0ab7b01772efe1
Source dataset
uspto-grants-1998_10
Patent number
US05817678

Reaction notes

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