HCID 21195131, compound → HCID 21195133, compound

HRID 399152Notes

Reaction equation

HRID 399152 reaction equation
[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[CH:12]=[C:11]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:10]=2)[CH:6]=[CH:5][CH:4]=1)#[N:2]>C(O)(=O)C.[Pd]>[NH2:2][CH2:1][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[CH:12]=[C:11]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:10]=2)[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 21195131HCID 21195131, compound

Product 1

HCID 21195133HCID 21195133, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 6-cyano-4'-(4-methoxyphenyl)-2,2':6',2"-terpyridine (4 mmol) and 480 mg of 10% Pd/C in 130 ml of acetic acid is hydrogenated (H2, 50 psi) at 45° C. for 22 hours. The reaction mixture is filtered and the solvent is stripped, the residue is triturated with methanol, filtered and dried to provide the desired product as the acetic acid salt.

Workup

  1. customat 45° C.
  2. customfor 22 hours
  3. filtrationThe reaction mixture is filtered
  4. customthe residue is triturated with methanol
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-39661129cdef41afa132f7c9a7a8bbb9
Source dataset
uspto-grants-1998_10
Patent number
US05817774

Reaction notes

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