(Chlorothio)formyl chloride → Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

25 g of chlorocarbonylsulphenyl chloride was added dropwise to 25 g of ethyl 3-aminocrotonate in 300 ml of toluene while being cooled with ice. The solution was heat-refluxed for 2 hours, and then cooled. The crystals precipitated were collected through filtration, and then washed twice with toluene to obtain 22.3 g of 4-methyl-5-ethoxycarbonyl-2-thiazolone as purple crystals.

Provenance & Evidence