反应详情

To a solution of ethyl(1RS,2SR,3SR)-1-(3,4-methylenedioxyphenyl)-3-phenylindane-2-carboxylate (650 mg, 1.68 mmol) in EtOH containing a few drops of THF was added 6M KOH (1.68 ml, 10.1 mmol). The resulting mixture was allowed to stir at room temperature overnight, then was concentrated under reduced pressure. The residue was partitioned between H2O and Et2O. The aqueous phase was acidified with 3M HCl and extracted several times with EtOAc. The combined EtOAc extracts were washed successively with H2O and saturated aqueous NaCl and dried (MgSO4). The solvent was removed in vacuo to afford an oil, which was crystallized from EtOAc/hexanes. The title compound was obtained as a solid (305 mg, 51%); m.p. 186°-187° C.

1. concentrationwas concentrated under reduced pressure
2. customThe residue was partitioned between H2O and Et2O
3. extractionextracted several times with EtOAc
4. washThe combined EtOAc extracts were washed successively with H2O and saturated aqueous NaCl
5. dry with materialdried (MgSO4)
6. customThe solvent was removed in vacuo
7. customto afford an oil, which
8. customwas crystallized from EtOAc/hexanes