Phenylboronic Acid → 2-Methyl-[1,1'-biphenyl]-4-carboxylic acid

HRID 399274Notes

Reaction equation

Br[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH3:11].[C:12]1(B(O)O)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:11][C:3]1[CH:4]=[C:5]([C:6]([OH:8])=[O:7])[CH:9]=[CH:10][C:2]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 821314-Bromo-3-methylbenzoic acid

Product 1

HCID 215218102-Methyl-[1,1'-biphenyl]-4-carboxylic acid

Procedure

The title compound was prepared from 4-bromo-3-methylbenzoic acid and benzeneboronic acid using a similar procedure to Description 15, as a pale yellow solid (89%).

Sources & evidence

ORD record: ord-64dc08d3d15e425bb1a2f472791e6503
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817833

Reaction notes

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