HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((5-Methoxy-1H-indol-6-yl)oxy)-N,N-dimethylethan-1-amine → 6-(2-Dimethylaminoethoxy)-5-methoxy-1-(2-methylbiphenyl-4-carbonyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((5-Methoxy-1H-indol-6-yl)oxy)-N,N-dimethylethan-1-amine | HCID 10537659 | — |
| Reactant | 4'-Acetyl-3'-methylbiphenyl-4-carboxylic acid | HCID 18970493 | — |
| Reactant | 2-Methyl-[1,1'-biphenyl]-4-carboxylic acid | HCID 21521810 | — |
| Product | 6-(2-Dimethylaminoethoxy)-5-methoxy-1-(2-methylbiphenyl-4-carbonyl)-1H-indole | HCID 18970498 | — |
Reaction Steps
The title compound was prepared from 2-methylbiphenyl-4-carboxylic acid (D23) and 6-(2-dimethylaminoethoxy)-5-methoxy-1H-indole (D13) using a similar procedure to Example 4 (80%). This was converted to its oxalate salt to afford a white solid. mp 152°-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05817833 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-d61895a51000490e9919b2b7aaa8ec2b |
| Source note | uspto-grants-1998_10 |