Butylamine → N-butyl-2-methylaniline

HRID 399307Notes

Reaction equation

HRID 399307 reaction equation
[C:1]1([CH3:15])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1OS(C(F)(F)F)(=O)=O.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:20][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[CH3:15])[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 5720252-Tolyl trifluoromethanesulfonate

Product 1

HCID 11073747N-butyl-2-methylanilineYield 67%

Procedure

General procedure B using 55.1 mg (0.229 mmol) of o-tolyltriflate and 34.0 μl (0.344 mmol) of n-butylamine gave 67% yield of N-butyl-2-methylaniline after silica gel chromatograph using 5% ethyl acetate in hexanes.

Sources & evidence

ORD record
ord-fdcf88cbec6c46eeba2949b035418134
Source dataset
uspto-grants-1998_10
Patent number
US05817877

Reaction notes

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