関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | 2-Chloro-4-nitroaniline | HCID 8492 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2'-Chloro-4'-nitrobenzenesulfonanilide | HCID 231836 | — |
反応手順
A mixture of 2-chloro-4-nitroaniline (4.33 g), benzenesulphonyl chloride (3.25 ml) and pyridine (2.5 ml) was stirred and heated to 100° C. for 18 hours. The mixture was cooled to ambient temperature and partitioned between methylene chloride and 2M aqueous hydrochloric acid. The organic phase was washed with water, dried and evaporated. The residue was recrystallised from ethyl acetate to give N-(2-chloro-4-nitrophenyl)benzenesulphonamide (6.07 g), m.p. 155°-157° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05821246 |
|---|
| 出典データセット | uspto-grants-1998_10 |
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| ORD ID | ord-c466971758344711aafc5413143c01f3 |
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| 出典メモ | uspto-grants-1998_10 |
|---|
