反应详情

温度

100 °C

A mixture of 2-chloro-4-nitroaniline (4.33 g), benzenesulphonyl chloride (3.25 ml) and pyridine (2.5 ml) was stirred and heated to 100° C. for 18 hours. The mixture was cooled to ambient temperature and partitioned between methylene chloride and 2M aqueous hydrochloric acid. The organic phase was washed with water, dried and evaporated. The residue was recrystallised from ethyl acetate to give N-(2-chloro-4-nitrophenyl)benzenesulphonamide (6.07 g), m.p. 155°-157° C.

1. temperatureThe mixture was cooled to ambient temperature
2. custompartitioned between methylene chloride and 2M aqueous hydrochloric acid
3. washThe organic phase was washed with water
4. customdried
5. customevaporated
6. customThe residue was recrystallised from ethyl acetate